David Nagib, PhD
The Ohio State University
Biography:
David grew up near Philadelphia as the eldest of four siblings in an Egyptian family with a strong love for teaching. His training entails research in asymmetric catalysis (with Prof. Scott Miller, Boston College, BSc 2006), photoredox organocatalysis (with Prof. David MacMillan, Princeton University, PhD 2011), organometallic mechanisms and MOF-enclosed catalysis (NIH Postdoc with Profs. F. Dean Toste and Omar Yaghi, UC Berkeley). Since 2014, David has taught at The Ohio State University, where he is the Harold and Betty Miller Professor of Organic Chemistry, as well as the College of Arts and Sciences Distinguished Professor of Chemistry and Biochemistry. His team’s research on radical- and carbene- mediated C-H and C-O functionalization is dedicated to streamlining the synthesis of complex, medicinally relevant molecules by employing big data technologies to design new modes of catalysis. These efforts have been recognized by the ACS (Cope Scholar), NIH, NSF, Lilly, Merck, Pfizer, and the Sloan, Brown, and Blavatnik Foundations. When not working alongside his awesome labmates, David enjoys running, trying new cuisines, and traveling with his wife and two young children.
Abstract:
Our research is focused on harnessing the untapped reactivity of abundant chemical motifs, including C-H and C-O bonds, which are typically inert to chemical manipulation. This strategy enables important applications, such as: (1) late-stage functionalization of medicines and complex biomolecules, or (2) bio-orthogonal couplings of proteins and nucleotides. To this end, we have recently developed new approaches for selective functionalization of alcohols, amines, and carbonyls, using a combination of open and closed shell processes that act in concert with one another. These radical- and carbene- mediated strategies have enabled discovery of new classes of reactivity to streamline the synthesis of complex molecules with biological and industrial significance.
David grew up near Philadelphia as the eldest of four siblings in an Egyptian family with a strong love for teaching. His training entails research in asymmetric catalysis (with Prof. Scott Miller, Boston College, BSc 2006), photoredox organocatalysis (with Prof. David MacMillan, Princeton University, PhD 2011), organometallic mechanisms and MOF-enclosed catalysis (NIH Postdoc with Profs. F. Dean Toste and Omar Yaghi, UC Berkeley). Since 2014, David has taught at The Ohio State University, where he is the Harold and Betty Miller Professor of Organic Chemistry, as well as the College of Arts and Sciences Distinguished Professor of Chemistry and Biochemistry. His team’s research on radical- and carbene- mediated C-H and C-O functionalization is dedicated to streamlining the synthesis of complex, medicinally relevant molecules by employing big data technologies to design new modes of catalysis. These efforts have been recognized by the ACS (Cope Scholar), NIH, NSF, Lilly, Merck, Pfizer, and the Sloan, Brown, and Blavatnik Foundations. When not working alongside his awesome labmates, David enjoys running, trying new cuisines, and traveling with his wife and two young children.
Abstract:
Our research is focused on harnessing the untapped reactivity of abundant chemical motifs, including C-H and C-O bonds, which are typically inert to chemical manipulation. This strategy enables important applications, such as: (1) late-stage functionalization of medicines and complex biomolecules, or (2) bio-orthogonal couplings of proteins and nucleotides. To this end, we have recently developed new approaches for selective functionalization of alcohols, amines, and carbonyls, using a combination of open and closed shell processes that act in concert with one another. These radical- and carbene- mediated strategies have enabled discovery of new classes of reactivity to streamline the synthesis of complex molecules with biological and industrial significance.
