Dr. Jie Zhou is a joint Assistant Professor in the Departments of Radiation and Cellular Oncology and Chemistry at the University of Chicago and a member of the University of Chicago Comprehensive Cancer Center (UCCCC). Her lab works at the intersection of chemistry, biology, and medicine to decode tumor-immune interactions in the tumor microenvironment and translate these insights into next-generation cancer immunotherapies. The Zhou Lab develops platforms for antibody and biologics discovery, engineering proteins, antibodies, viruses, and cells for therapeutic applications. The lab builds, maintains, and screens diverse biologics libraries (humanized nanobody/VHH, Fab, affibody, and peptide) using phage, yeast, mammalian, and viral display, paired with computational protein design. By integrating chemical design, molecular engineering, and immune regulation, Zhou Lab aims to enable precision immunotherapies and accelerate the path from discovery to the clinic.