Dr. Alyssa Coyne is an assistant professor in the Department of Neurology and Brain Science Institute at Johns Hopkins University School of Medicine. As a PhD student in the lab of Dr. Daniela Zarnescu at the University of Arizona, she studied the dysregulation of mRNA transport and translation in Drosophila models of TDP-43 proteinopathies. During her postdoctoral work in Dr. Jeffrey Rothstein’s lab at Johns Hopkins, she used iPSNs and postmortem human tissues to characterize nuclear pore complex injury in ALS. Now, her lab seeks to understand early events that give rise to and/or propagate pathogenic cascades in neurodegenerative diseases such as ALS and FTD. Currently, our primary focus is centered upon understanding the role of the ESCRT-III pathway in nuclear pore complex alterations, TDP-43 loss of function and mislocalization, and endolysosomal dysfunction in neurodegeneration using iPSC, postmortem human tissue, and mouse and Drosophila models of ALS/FTD.