Gerald I. Shulman, MD, PhD, is the George R. Cowgill Professor of Physiological Chemistry at Yale University, Co-Director of the Yale Diabetes Research Center, and an Investigator Emeritus of the Howard Hughes Medical Institute. He pioneered the integration of magnetic resonance spectroscopy, stable isotopes, and mass spectrometry to reveal how glucose and fat metabolism go awry in humans. His discoveries established fundamental mechanisms linking ectopic lipid accumulation to liver and muscle insulin resistance and advanced new therapeutic approaches for type 2 diabetes and metabolic liver disease. He has trained more than 135 graduate students and postdoctoral fellows, many now leading laboratories and research centers worldwide. His honors include the ADA Banting Medal for Lifetime Scientific Achievement and election to the National Academy of Sciences, National Academy of Medicine, and American Academy of Arts and Sciences.