Visceral adiposity is associated with insulin resistance and type 2 diabetes. Given this association, our recently published adipocyte-specific C/EBPA knockout (CEBPA_ASKO) mice which exhibit loss of gonadal white adipose tissue are a valuable model for studying adipose contributions to glucose homeostasis. Consistent with published models of lipodystrophy such as mice with adipocyte-specific PPARG loss, Cebpa_ASKO mice on 60% high-fat diet (HFD) showed signs of insulin resistance, including a 2.7-fold elevation in fasting plasma insulin (p=0.01) and a 35.7% increase in ITT AUC (p=0.008). Contrary to expected glucose intolerance, HFD-fed Cebpa_ASKO mice had a 0.6-fold reduction in fasting blood glucose (p=0.02) and a 37.2% decrease in GTT AUC (p