Lawrence Kazak, PhD
Associate Professor
McGill University
Research in my lab started in 2018 at the Rosalind and Morris Goodman Cancer Institute and Department of Biochemistry at McGill University, where I am currently an Associate Professor. I hold a Tier 2, Canada Research Chair in Adipocyte Biology. My research aims to define the molecular mechanism regulating energy balance by adipose tissue. My lab has identified the effector proteins regulating UCP1-independent thermogenesis and the mechanisms regulating their expression and activity. My lab uses mice with engineered mutations in putative energy consuming pathways to examine the role of these genes over the control of metabolic rate and obesity-accelerated metabolic disturbances. A complete understanding of adipocyte thermogenesis cannot be established without knowledge of the involved players and whether cells use a single pathway or parallel pathways. I am committed to the development of molecular tools and mouse models to resolve the quantitative contribution of all pathways of thermogenesis.
